Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
Shoba G, Joseph T, Majeed M, Rajendran R and Srinivas PS. Planta Med. 1998; 64(4): 353-356
Curcumin C3 Complex® + BioPerine® (2000 mg + 20 mg/day).
Piperine enhances the serum concentration and bioavailability of curcumin in both rats and human volunteers. Relative bioavailability of curcumin when combined with BioPerine® is 2000%.
Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation
Vladimir B, Majeed M and Edward N. Nutri Res. 1999; 19(3): 381-388
Supplementation of beta-carotene with BioPerine® increased the serum levels of beta-carotene almost by 2 folds.
Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation
Vladimir B, Majeed M and Lakshmi P. J Nutr Biochem. 2000; 11: 109-113
BioPerine® increased the serum levels of coenzyme Q10 by 31% as compared to control.
A clinical evaluation comparing the bioavailability of two buffered vitamin C supplements in healthy, non-smoking males
Kirenia L, Samantha F, Diane RK and Douglas K. FASEB J. 2008; 22(S2): 689
Vitamin C with BioPerine® displayed a faster rate of absorption than vitamin C without BioPerine®.
A clinical study on iron deficiency anemia with BioIron
Majeed M, Vaidyanathan P, Kiradi P, Lad PS and Vuppala KK. Int J Ayurveda Pharma Res. 2016; 4(10): 18-24
BioIron (consisting of 8.5 mg of elemental iron and 2.5 mg of BioPerine®) was observed to directly affect iron stores of the body. BioIron was found to be safe and effective in the management of iron deficiency anaemia without any adverse events.
Piperine-pro-nanolipospheres as a novel oral delivery system of cannabinoids: Pharmacokinetic evaluation in healthy volunteers in comparison to buccal spray administration
Cherniakov I, Izgelov D, Barasch D, Davidson E, Domb AJ, Hoffman A. J Control Release 2017; 266: 1-7
BioPerine® displayed a 3-fold increase in Cmax and a 1.5-fold increase in AUC for Tetrahydrocanabinol (THC); and a 4-fold increase in Cmax and a 2.2-fold increase in AUC for cannabidiol (CBD) as compared to THC and CBD alone respectively.
Curcumin downregulates NF-κB and related genes in patients with multiple myeloma: Results of a Phase I/II study
Vadhan-Raj S, Weber DM, Wang M, Giralt SA, Thomas SK, Alexanian R, Zhou X, Patel P, Bueso-Ramos CE, Newman RA and Aggarwal BB. Blood 2007; 110: Abstract 1177
Curcumin C3 Complex® + BioPerine® (up to 12 g + 10 mg/day).
Exerted anti-inflammatory effects by down-regulating NF-κB, STAT3 and COX-2 expression.
Improvement of sulphur mustard – induced chronic pruritus, quality of life and antioxidant status by curcumin: Results of a randomized double-blind placebo-controlled trial
Panahi Y, Sahebkar A, Amiri M, Davoudi SM, Beiraghdar F, Hoseininejad SL and Kolivand M. Br J Nutr. 2012; 108(7): 1272-1279
Curcumin C3 Complex® + BioPerine® (1000 mg + 10 mg/day).
Supplementation significantly increased the activity of antioxidant enzymes, which helps to fight the oxidative stress. Oxidative stress plays an important role in pathogenesis of sulphur mustard complications.
A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard induced cutaneous complications
Panahi Y, Sahebkar A, Parvin S and Saadat A. Ann Clin Biochem. 2012; 49: 580-588
Curcumin C3 Complex® + BioPerine® (1000 mg + 10 mg/day) for 4 weeks.
Supplementation significantly reduced the serum interleukin-8 levels as well as High-sensitivity C-reactive Protein (hs-CRP) levels. It also helped to reduce the pruritus score as evident from a marked decline in pruritus score.
Proof of concept of randomized controlled study of Curcumin C3 Complex® as an adjunct treatment in schizophrenia: Effects on negative and depressive symptoms
Woodbury-Farina M, Cernovsky Z, Chiu S, Bureau Y, Campbell R, Houicin J, Terpstra K, Raheb H, Husni M and Badmaev V. Cultivating Natural Bioactives: International Conference, Canada. July 9 to 11, 2012; S2-S3
Curcumin C3 Complex® (4 g and 1 g) and BioPerine® (5 mg per 1 g of Curcumin C3 Complex®) for 12 weeks. Both 1 and 4 g supplementation improved the negative symptoms of schizophrenia over 12 weeks.
Evaluation of a multi-herb supplement for erectile dysfunction: A randomized double-blind, placebo-controlled study.
Shah GR, Chaudhari MV, Patankar SB, Pensalwar SV, Sabale VP, Sonawane NA. BMC Complement Altern Med. 2012;12: 155
A multi-herbal formulation containing BioPerine® (5 mg), administered, 2 capsules twice daily (360 mg) in men for 12 weeks was well tolerated and more effective than placebo in improving sexual function.
A pilot double-blind, randomized, placebo-controlled trial of Curcumin/Bioperine for lung cancer chemoprevention in patients with chronic obstructive pulmonary disease
Sharafkhaneh A, Lee JJ, Liu D, Katz R, Caraway N, Acosta C, Wistuba II, Aggarwal B, Dickey B, Moghaddam SJ, Hanania N, Newman R, Abdel-Monem H, Nguyen NB, Farhangfar CJ, Hong WK and Kurie JM. Advances in Lung Cancer 2013; 2(3): 62-69.
Curcumin C3 Complex® + BioPerine® (1 g + 5 mg) for a month, 1.5 g + 5 mg for another month, and 2 g + 5 mg for an additional month.
Reversed the cytological parameter abnormalities in patients with chronic obstructive pulmonary disease.
Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers
Volak LP, Hanley MJ, Masse G, Hazarika S, Harmatz JS, Badmaev V, Majeed M, Greenblatt DJ and Court MH. Br J Clin Pharmacol. 2013; 75(2): 450-462
Curcumin C3 Complex® + BioPerine® (4 g and 24 mg).
Piperine-enhanced curcuminoid preparation is unlikely to result in a clinically significant interaction involving CYP3A, CYP2C9 or the paracetamol conjugation enzymes.
Curcuminoids modulate pro-oxidant-antioxidant balance, but not the immune response to heat shock protein 27 and oxidized LDL in obese individuals
Sahebkar A, Mohammadi A, Atabati A, Rahiman S, Tavallaie S, Iranshahi M, Akhlaghi S, Ferns GA and Ghayour-Mobarhan M. Phytother Res. 2013; 27(12): 1883-1888
Curcumin C3 Complex® + BioPerine® (1000 mg + 10 mg/day).
Supplementation mitigates oxidative stress in obese individuals.
Effects of supplementation with curcuminoids on dyslipidemia in obese patients: A randomized crossover trial
Mohammadi A, Sahebkar A, Iranshahi M, Amini M, Khojasteh R, Ghayour-Mobarhan M and Ferns GA. Phytother Res. 2013; 27(3): 374-379
Curcumin C3 Complex® + BioPerine® (1000 mg + 10 mg/day).
Supplementation reduced the lipid profile parameters including serum triglycerides.
Curcuminoid treatment for knee osteoarthritis: A randomized double-blind placebo-controlled trial
Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A and Sahebkar A. Phytother Res. 2014; 28(11): 1625-1631
Curcumin C3 Complex® + BioPerine® (1500 mg + 15 mg/day) for 6 weeks.
Supplementation showed significant decrease in pain, physical function and stiffness. The LPFI and VAS scores showed a significant reduction. Also there was 84% decrease in pain of the subjects who took naproxen along with curcuminoids.
Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: A randomized double-blind placebo-controlled cross-over trial
Moohebati M, Yazdandoust S, Sahebkar A, Mazidi M, Sharghi-Shahri Z, Ferns G and Ghayour-Mobarhan M. ARYA Atheroscler. 2014; 10(5): 280-286
Curcumin C3 Complex® + BioPerine® (1000 mg + 5 mg/day) for 4 weeks.
Curcuminoids was not associated with any significant alteration in circulating small density LDL concentrations.
Investigation of the effects of curcumin on serum cytokines in obese individuals: A randomized controlled trial
Ganjali S, Sahebkar A, Mahdipour E, Jamialahmadi K, Torabi S, Akhlaghi S, Ferns G, Parizadeh SM and Ghayour-Mobarhan M. Sci World J. 2014; 898361
Curcumin C3 Complex® + BioPerine® (1000 mg + 10 mg/day).
Curcumin was able to modulate the inflammatory response in obese subjects. Supplementation significantly reduced the serum concentrations of interleukin 1 , vascular endothelial growth factor and interleukin-4.
Lipid modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: Results of a randomized controlled trial
Panahi Y, Khalili N, Hosseini MS, Abbasinazari M and Sahebkar A. Complement Ther Med. 2014; 22(5): 851-857.
Curcumin C3 Complex® + BioPerine® (1000 mg + 10 mg/day).
Combination resulted in greater reduction of serum triglycerides, total cholesterol, serum low density lipoprotein-cholesterol, non-high-density lipoprotein-cholesterol, lipoprotein and increase in high density lipoprotein-cholesterol concentration.
Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: A randomised, double-blind, placebo-controlled, cross-over investigation
Wightman EL, Reay JL, Haskell CF, Williamson G, Dew TP and Kennedy DO. Br J Nutr. 2014; 112(2): 203–213
Piperine enhanced the cerebral blood flow in the frontal cortex as assessed using near-IR spectroscopy. This effect was independent of resveratrol.
Antioxidant and anti-inflammatory effects of curcuminoid – piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M and Sahebkar A. Clin Nutr. 2015; 34(6): 1101-1108
Curcumin C3 Complex® + BioPerine® (1000 mg + 10 mg/day).
Supplementation significantly reduced the serum hs-CRP concentrations and improved the biomarkers of inflammation and oxidative stress.
Impact of supplementation with curcuminoids on systemic inflammation in patients with knee osteoarthritis: Findings from a randomized double-blind placebo-controlled trial
Rahimnia AR, Panahi Y, Alishiri G, Sharafi M and Sahebkar A. Drug Res (Stuttg). 2015; 65(10): 521-525
Curcumin C3 Complex® + BioPerine® (1500 mg + 15 mg/day) for 6 weeks.
Significant improvement in clinical symptoms of osteoarthritis in curcumin-treated subjects because of a local anti-inflammatory effect in osteo-cartilaginous tissue.
Short-term curcuminoid supplementation for chronic pulmonary complications due to sulfur mustard intoxication: Positive results of a randomized double-blind placebo-controlled trial
Panahi Y, Ghanei M, Bashiri S, Hajihashemi A and Sahebkar A. Drug Res (Stuttg). 2015; 65(11): 567-573
Curcumin C3 Complex® + BioPerine® (1500 mg + 15 mg/day) for 4 weeks.
Short-term adjunctive therapy with curcuminoids can suppress systemic inflammation in patients suffering from sulfur mustard-induced chronic pulmonary complications.
Investigation of the efficacy of adjunctive therapy with bioavailability-boosted curcuminoids in major depressive disorder
Panahi Y, Badeli R, Karami GR and Sahebkar A. Phytother Res. 2015; 29(1): 17-21
Curcumin C3 Complex® + BioPerine® (1000 mg + 10 mg/day).
Supplementation may be used as a safe and effective add-on to standard antidepressants in patients with major depressive disorder (MDD).
An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial
Esmaily H, Sahebkar A, Iranshahi M, Ganjali S, Mohammadi A, Ferns G and Ghayour-Mobarhan M. Chin J Integr Med. 2015; 21(5): 332-338
Curcumin C3 Complex® + BioPerine® (1000 mg + 10 mg/day) for 4 weeks.
Supplementation showed a significant reduction in the mean beck anxiety inventory score and was able to show significant anti-anxiety effect. Also the bioavailability of curcuminoids had the advantage by the addition of BioPerine®.
Effects of curcuminoids-piperine combination on systemic oxidative stress, clinical symptoms and quality of life in subjects with chronic pulmonary complications due to sulphur mustard: A randomized controlled trial
Panahi Y, Ghanei M, Hajhashemi A and Sahebkar A. J Diet Suppl. 2016; 13(1): 93-105
Curcumin C3 Complex® + BioPerine® (1500 mg + 15 mg/day).
Supplementation mitigated the oxidative stress as indicated by a decrease in malondialdehyde (MDA) levels and increased health related quality of life in patients having sulphur mustard-induced pulmonary complications and suggested curcuminoids as “safe adjuvants”.
Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: Results of a randomized controlled trial
Panahi Y, Alishiri GH, Parvin S and Sahebkar A. J Diet Suppl. 2016; 13(2): 209-220
Curcumin C3 Complex® + BioPerine® (1500 mg + 15 mg/ day).
Reduced oxidative stress with increase in serum levels of superoxide dismutase and glutathione and decrease in the malondialdehyde concentration.
Adjunctive therapy with curcumin for peptic ulcer: A randomized controlled trial
Khonche A, Biglarian O, Panahi Y, Valizadegan G, Soflaei SS, Ghamarchehreh ME, Majeed M and Sahebkar A. Drug Res (Stuttg). 2016; 66(8): 444-448
Curcumin C3 Complex® + BioPerine® (500 mg + 5 mg/day).
Adjunctive therapy with curcumin showed greater improvement of dyspepsia symptoms.
Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial
Panahi Y, Hosseini MS, Khalili N, Naimi E, Simental-Mendía LE, Majeed M and Sahebkar A. Biomed Pharmacother. 2016; 82: 578–582
Curcumin C3 Complex® + BioPerine® (1000 mg + 10 mg/day).
Reduced serum concentrations of pro-inflammatory cytokines.
Effects of supplementation with curcumin on serum adipokine concentrations: A randomized controlled trial
Panahi Y, Hosseini MS, Khalili N, Naimi E, Soflaei SS, Majeed M and Sahebkar A. Nutr. 2016; 32(10): 1116-1122
Curcumin C3 Complex® + BioPerine® (1 g + 10 mg/day).
Elevated serum adiponectin and reduced leptin concentrations.
Influence of exercise training with resveratrol supplementation on skeletal muscle mitochondrial capacity
Polley KR, Jenkins N, O’Connor P and McCully K. Appl Physiol Nutr Metab. 2016;1: 26-32
This study demonstrated that even low intensity exercise training, when combined with BioPerine®/Resveratrol combination, seems enough to afford the benefits of high intensity exercises for increasing muscle strength. This may be especially useful for populations unable to perform high intensity exercises.
Curcuminoids plus piperine modulate adipokines in type 2 diabetes mellitus
Panahi Y, Khalili N, Sahebi E, Namazi S, Atkin SL, Majeed M and Sahebkar A. Curr Clin Pharmacol. 2017; 12(4): 253-258
Curcumin C3 Complex® + BioPerine® (1 g + 10 mg/day).
Combination reduced the serum levels of leptin and improved leptin: adiponectin ratio.
Curcumin and piperine supplementation and recovery following exercise induced muscle damage: A randomized controlled trial
Delecroix B, Abaiïdia AE, Leduc C, Dawson B and Dupont G. J Sports Sci Med. 2017; 16(1): 147-153
Curcumin C3 Complex® + BioPerine® (2000 mg + 20 mg, 3 times a day).
Supplementation before and after exercise can attenuate muscle damage.
Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial
Panahi Y, Khalili N, Sahebi E, Namazi S, Reiner Z, Majeed M and Sahebkar A. Complement Ther Med. 2017; 33: 1-5
Curcumin C3 Complex® + BioPerine® (1000 mg + 10 mg/day).
Significantly reduced total cholesterol, non-HDL-C and elevated serum HDL-C levels. It also reduces the risk for cardiovascular events in Type 2 Diabetes.
Long-term stabilisation of myeloma with curcumin
Zaidi A, Lai M and Cavenagh J. BMJ Case Rep. 2017. doi:10.1136/bcr-2016-218148.
Curcumin C3 Complex® + BioPerine® (8 g + 5 mg/day) for 60 months.
Blocks the progression of myeloma with normal range of blood cell counts. Also maintained a good quality of life throughout the study.
Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: A randomized controlled trial
Panahi Y, Khalili N, Sahebi E, Namazi S, Karimian MS, Majeed M and Sahebkar A. Inflammopharmacol. 2017; 25(1): 25-31
Curcumin C3 Complex® + BioPerine® (1000 mg + 10 mg/day).
Elevates total antioxidant capacity, while reducing lipid peroxidation.
Effects of turmeric and curcumin dietary supplementation on human gut microbiota: A double-blind, randomized, placebo-controlled pilot study
Peterson CT, Vaughn AR, Sharma V, Chopra D, Mills PJ, Peterson SN and Sivamani RK. J Evid Based Integr Med. 2018; 23: 1-8
Group A: Turmeric powder (1000 mg) + BioPerine® (1.25 mg) (n=6)
Group B: Curcumin C3 Complex® (1000 mg) + BioPerine® (1.25 mg) (n=5)
Group C: Placebo (1000 mg) (n=3) for 2 Months.
The study found that both turmeric and curcuminoids have similar qualitative effects on the intestinal bacterial population. However, curcuminoids has a far larger quantitative effect indicating that curcuminoids in turmeric are the decisive components in influencing the bacterial population. Thus, curcuminoids have an unique role and effect on the gut microbiome.
Dietary supplements as surrogate of mediterranean diet in healthy smoking subjects.
Vasto S, Accardi G, Aiello A, Di Gaudio F, Barera A, Indelicato S, Galimberti D, Italiano E, Monastero R, Rizzo C, Caruso C and Candore G. Rejuvenation Res. 2018; 21(1): 37-43
BioPerine® present in dietary supplements exerts antioxidant and anti-inflammatory effects and could be useful in delaying age-related diseases.
Effects of curcuminoids plus piperine on glycemic, hepatic and inflammatory biomarkers in patients with type 2 diabetes mellitus: A randomized double-blind placebo-controlled trial
Panahi Y, Khalili N, Sahebi E, Namazi S, Simental-Mendía LE, Majeed M and Sahebkar A. Drug Res (Stuttg). 2018; 68(7): 403-409
Curcumin C3 Complex® + BioPerine® (500 mg + 5 mg/day).
Supplementation reduced the serum glucose and improved liver health enzymes in type 2 diabetes mellitus.
Translating curry extract to novel therapeutic approach in schizophrenia: The emerging role of epigenetics signaling
Chiu SS, Woodbury-Farina M, Terpstra K, Badmaev V, Cernovsky Z, Bureau Y, Jirui Hou J, Raheb H, Husni M, Copen J, Shad M, A Carriere A and Khazaei Z. Planta Med. 2018; 5(S 01): S8-S9
Curcumin C3 Complex® combined with BioPerine® (Supercurcumin™) improved core symptoms and cognitive deficits in patients diagnosed as schizophrenia modulating epigenetic target histone deacetylase (HDAC).
Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial
Panahi Y, Valizadegan G, Ahamdi N, Ganjali S, Majeed M and Sahebkar A. J Cell Biochem. 2019; 120(9): 15989-15996
Curcumin C3 Complex® + BioPerine® (500 mg + 5 mg) for 12 weeks.
Supplementation significantly reduced
- Erythrocyte sedimentation rate
- Alanine aminotransferase
- Aspartate aminotransferase
- Alkaline phosphatase
- Cholesterol
- Low density lipoprotein cholesterol
- Iron
- Increased total iron binding capacity
- Improved Nonalcoholic fatty liver disease (NAFLD) severity
Pharmacokinetics, pharmacodynamics, and PKPD modelling of curcumin in regulating antioxidant and epigenetic gene expression in healthy human volunteers
Cheng D, Li W, Wang L, Lin T, Poiani G, Wassef A, Hudlikar R, Ondar P, Brunetti L and Kong AN. Mol Pharm. 2019; 16(5): 1881-1889
Curcumin C3 Complex® + BioPerine® (4 g + 20 mg).
Oral administration of curcumin resulted in detectable levels of its metabolite, curcumin glucuronide, but more importantly, it increased the gene expression of antioxidant genes NRF2, HO-1, and NQO1 and suppressed epigenetic genes HDAC1, HDAC2, HDAC3, and HDAC4.
Exploratory study of curcumin isolated from turmeric Curcuma longa, the putative histone deacetylase inhibitor, as added-on strategy to antipsychotics in treating negative symptoms and neuro-cognitive deficits in schizophrenia.
Chiu S, Farina MW, Terpstra K, Badmaev V, Cernovsky Z, Bureau Y, Raheb H, Husni M, Copen J, Shad M, Jirui H, Campbell R, Khazaeipool Z and Carriere A. Adv Res J Multidisciplinary Discov. 2019; 40(2): 6-15
Supercurcumin™ (Curcumin C3 Complex® + BioPerine®; 1 g + 5 mg)
Supercurcumin™ (Curcumin C3 Complex® + BioPerine® ; 4 g + 20 mg) for 16 weeks
Curcumin was safe and beneficial when combined with piperine in schizophrenia.
Supercurcumin™ was well tolerated with no serious adverse events.
Effects of supplementation with curcuminoids on serum adipokines in critically ill patients: A randomized double blind placebo controlled trial.
Shadnoush M, Zahedi H, Norouzy A, Sahebkar A, Sadeghi O, Najafi A, Hosseini S, Qorbani M, Ahmadi A, Hossein S, Mohammad A and Hosseinzadeh Attar J.Phytother Res. 2020; 34(12): 3180-3188
Curcumin C3 Complex® (500 mg) + BioPerine® (5 mg) for 7 days.
Supplementation with curcuminoids significantly reduced serum levels of leptin but had no significant effect on adiponectin levels in critically ill patients with traumatic brain injury (TBI).
Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial
Saberi-Karimian M, Keshvari M, Ghayour-Mobarhan M, Salehizadeh L, Rahmani S, Behnam B, Jamialahmadi T, Asgary S and Sahebkar A. Complement Ther Med. 2020: 49: 102322.
One capsule containing 500 mg Curcumin C3 Complex® + 5 mg BioPerine® daily.
Curcumin supplementation can improve serum levels of inflammatory cytokines in subjects with NAFLD and this might be at least partly responsible for the anti-steatotic effects of curcuminoids.
An open-label pilot study on macumax supplementation for dry-type age-related macular degeneration.
Majeed M, Majeed S and Nagabhushanam K. J Med Food. 2020. doi:10.1089/jmf.2020.0097.
Macumax®, a novel mixture of a phyto-mineral nutritional supplement containing ZeaLutein®
Macumax®, a novel mixture of a phyto-mineral nutritional supplement containing ZeaLutein® (consisting of lutein, zeaxanthin, and BioPerine®), extracts of bilberry, saffron, and zinc monomethionine. Supplementation of Macumax® was found to be safe and maintained eye health without further progression of early-stage dry-type Age-related macular degeneration AMD.
Supplementation with resveratrol, piperine and alpha tocopherol decreases chronic inflammation in a cluster of older adults with metabolic syndrome
Pastor RF, Repetto MG, Lairion F, Lazarowski A, Merelli A, Zulma Carabetti M, Pastor I, Pastor E, Valeria LV, Bavasso CA and Liermoli RH. Nutrients 2020; 12(10): 3149
Piperine in combination with resveratrol and alpha-tocopherol decreased chronic inflammation in Metabolic Syndrome patients in elderly subjects as signified by the decrease in plasma ferritin levels and ultra-sensitive C-reactive protein.
Effect of curcumin on severity of functional dyspepsia: A triple blinded clinical trial
Panahi Y, Karbasi A, Valizadegan G, Ostadzadeh N, Sofaei SS, Jamialahmadi T, Majeed M and Sahebkar A. Adv Exp Med Biol. 2021;1308: 119-126
500 mg Curcuminoids (Curcumin C3 Complex® 500 mg + BioPerine® 5 mg) + 40 mg Famotidine
500 mg Placebo + 40 mg Famotidine
Supplementation with Curcuminoids as an adjunct therapy eradicated Helicobacter pylori infection and improved clinical symptoms of dyspepsia. Hence, considering the good safety profile of Curcuminoids and its pleiotropic actions, could be used as an efficacious agent in functional dyspepsia.
Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients: A randomized double-blind placebo-controlled trial.
Zahedi H, Hosseinzadeh-Attar MJ, Shadnoush M, Sahebkar A, Barkhidarian B, Sadeghi O, Najafi A, Hosseini S, Qorbani M, Ahmadi A, Ardehali SH and Norouzy A. Phytother Res. 2021. doi:10.1002/ptr.7179.
In a clinical study on 62 ICU admitted patients with traumatic brain injury, C3 Complex® (500 mg) with BioPerine® was shown to improve inflammatory and oxidative stress markers. Additionally, nutritional status of these critically ill patients also improved as shown by APACHEII and NUTRIC scores.
Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19: A randomized clinical trial.
Pawar KS, Mastud RN, Pawar SK, Pawar SS, Bhoite RR, Bhoite RR, Kulkarni MV and Deshpande AR. Front Pharmacol. 2021; 12: 669362
Curcumin C3 Complex® + BioPerine® (525 mg + 2.5 mg, 2 times a day), 14 days.
Patients in the group who received the C3 Complex® + BioPerine® adjuvant treatment showed quicker symptomatic recovery (of fever, cough, sore throat, breathlessness), had a lower incidence of red-flag signs, and better ability to maintain oxygen saturation >94% on room air only. The D-dimer levels were less severe in C3-group than in the non-C3-group.