The corporation announced in November it was taking legal action against DNP International for allegedly infringing patents protecting the use of its BioPerine® and Forslean extracts. Respect for intellectual property is critical in sustaining the spirit of research and innovation and in making these efforts economically worthwhile. Sabinsa Corporation has built a sizeable intellectual property portfolio and actively advocates the protection of intellectual property.
A thermonutrient like Sabinsa’s multipatented BioPerine® (min. 98% piperine content) can enhance the process of nutrient absorption by enhancing thermogenesis. The leading theory of food induced thermogenesis relates to the autonomous nervous system. The autonomous nervous system is represented by two main receptors in the gastrointestinal tract, the alpha and beta adrenergic receptors.
Most of the food or thermonutrientinduced thermogenesis is facilitated by beta receptors, which include a compound known as cyclic adenosine 3’, 5’ monophosphate (cAMP). The role of cAMP as a “second messenger” to the hormonal and enzymatic actions in the body is well recognized. When thermogenesis occurs, the demand for fresh nutrients to sustain the metabolic processes rapidly increases.
The first patent on the use of BioPerine® as an enhancer of nutrient bioavailability, (U.S. Patent 5,536,506) was issued in 1996. Patent 5,744,161 dated April 28, 1998, covers the use of piperine as a bioavailability enhancer for a broader range of nutritional supplements.
The salient features of the oral, topical and parenteral compositions with piperine described in the patent, include increased gastrointestinal absorption and improved transfer of nutrients / biological compounds through various biological membrane barriers in the body, as well as enhanced systemic utilization of these compounds. The patent also describes a new process for the extraction and purification of piperine.
The patent refers to the USE OF PIPERINE, specifically to increase the bioavallability of compounds such as vitamins, amino acids and minerals in nutritional supplement formulations. It is not a product patent and does not infringe upon the export of black pepper, piperine or pepper oleoresin from India, Indonesia or Sri Lanka. Based on documented research and detailed clinical studies, the patent only serves to render credibility to the use of a piperine as an enhancer of nutrient bioavailability.