An Ingredient of Sabinsa Last Updated :: September 09, 2009
 
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BioPerine® and Curcumin

The objective of this study was to evaluate the bioavailability of curcumin co-administered with BioPerine® in animals and human volunteers. Curcumin is a phenolic phytochemical obtained from turmeric (Curcuma longa L). It has been scientifically researched that Curcumin has effective therapeutic outcome acting as an antioxidant, anti-inflammatory, antispasmodic, anticoagulant, anticarcinogenic, immunomodulatory activities and even in wound healing. It has been found that the therapeutic effectiveness of curcumin is often limited due to its poor absorption from the GI tract. When taken orally only traces appear in the blood whereas most of the dose is excreted though the feces.

Piperine was found to enhance the bioavailability of Curcumin both in preclinical studies and in studies on human volunteers.

 

Bioavailability Studies: Curcumin & BioPerine®

Pharmacokinetic parameters (mean ± SEM) of oral curcumin 2g/kg alone and in combination with BioPerine® 20 mg/kg in rats (n=6).

Parameters

Curcumin alone
2 g/kg

Curcumin + BioPerine®
2g/kg + 20mg/kg

Cmax (mg/ml)

1.35 ± 0.23

1.80 ± 0.16

Tmax (h)

0.83 ± 0.05

1.29 ± 0.23

t1/2(a) (h)

0.31 ± 0.07

0.47 ± 0.03

t1/2(el) (h)

1.70 ± 0.58

1.05 ± 0.18

AUC(0 - tn) (mg/h/ml)

2.36 ± 0.28

3.64 ± 0.31

Vd (L/kg)

1366.00 ± 248.70

782.90 ± 193.90

Cl(L/h)

713.00 ± 12.00

495.90 ± 37.08

P < 0.02: Statistical significance by Student’s "t" test

Cmax: Maximum serum concentration

Tmax: Time to reach maximal serum concentration

t1/2(a): Absorption half-life

t1/2(el): Elimination half-life

AUC(0 - tn): Area under the concentration time curve

Vd: Volume of distribution

Cl: Total clearance


Effect of BioPerine® on Serum Concentrations of Curcumin in Rats.

 

Bioavailability Studies - Curcumin & BioPerine®

Pharmacokinetic parameters (mean + SEM) of oral curcumin 2 g alone and in combination with BioPerine® 20 mg in normal healthy volunteers (n=8).

Parameters

Curcumin alone
2 g

Curcumin+BioPerine®
2g+20mg

Cmax (mg/ml)

0.006 ± 0.005

0.18 ± 0.03

Tmax (h)

1

0.69 ± 0.07

t1/2(a) (h)

-

0.11 ± 0.02

t1/2(el) (h)
-

0.41 ± 0.17

AUC(0 - tn) (mg/h/ml)

0.004

0.08 ± 0.01

Vd (L/kg)

-

202.60 ± 78.94

Cl(L/h)
-

7.33 ± 1.25

F (Relative bioavailablility)

-

2000%



Effect of BioPerine® on Serum Concentrations of Curcumin In Human Volunteers



Disclaimer

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

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